Nordlys 1940nm does more than smooth the surface. In a first-in-human study, it reversed 83% of age-associated epigenetic changes. Combined with DNA-repair science and a philosophy of accountability, this is an approach to skin longevity that treats the biology, measures the result, and is honest about what remains unproven.

Key takeaways before we go deep:

The science: not just a wavelength, a biological reset

A 2026 Nature Scientific Reports study found that three sessions of 1940nm NAFL rewrote the epigenetic code of treated skin. The study identified 635 differentially methylated regions, and 83% of CpG sites reversed their age trajectory. The changes were durable at six months.

Nature Scientific Reports: hexbin density plot showing methylation shifts opposite to the direction of aging after 1940nm treatment
Nature Scientific Reports: hexbin density plot showing methylation shifts opposite to the direction of aging after 1940nm treatment

The pathways activated matter as much as the headline number: epidermal differentiation, collagen organization, wound response, and stem-cell maintenance. That is not cosmetic improvement. It is cellular rejuvenation, measured at the level of the epigenome.

83%of CpG sites reversed their age-associated methylation trajectory
635differentially methylated regions identified
6 modurability of the epigenetic changes

The precedent: Fraxel 1927 and skin cancer reduction

There is important context from an adjacent wavelength. Dr. Avram's group at MGH showed that NAFL at 1927nm delivered roughly a 50% reduction in skin cancers over six years; untreated controls were 2.65 times more likely to develop new carcinomas. The mechanism is the one that matters across this whole field of medicine: clearing the photodamaged field. We cover field treatment in depth in our skin cancer prevention and CO2 laser pages.

Given that Fraxel 1927 demonstrated a 50% reduction in skin cancer, we would expect a similar trajectory from 1940nm, but the activation is not quite the same.

The nuance: 1940nm activates longevity and youthful markers, including stem-cell maintenance, collagen organization and WNT signalling. That is the kind of remodeling we would expect from CO2, but with dramatically less downtime, which makes it a compelling alternative for patients who want biological depth without weeks of recovery.

Honest caveat. The 1940nm epigenetic data is from a first-in-human split-face study (n=22). It is compelling pilot evidence, not a confirmed standard of care. The Avram skin-cancer data used 1927nm specifically. We do not yet have long-term cancer-prevention data at 1940nm, but the biological direction is promising.

Ask about Nordlys at deRMA Skin Institute. Dr. Sajic delivers every laser parameter personally in Guelph. Book now →

Accountability: settings decide the result

Not all lasers are built the same, and neither are the settings. Even with the Nordlys 1940nm, the parameters determine whether you are activating longevity pathways or just creating a cosmetic glow. Beauty and longevity are not the same thing. What we strive for is skin vitality, longevity and resilience.

So we measure what the laser does. Before, during and after. If the biology is not changing, we recalibrate. That is what accountability means in practice:

DNA repair science: a laser in a bottle

The laser rewrites the epigenetic code. But what if you could extend that biological reset every day, without the clinic? That is why we built Rejuvenat.

Research poster: Addressing the Field, Not Just the Lesion — translational study of skin quality and actinic keratoses
Research poster: Addressing the Field, Not Just the Lesion — translational study of skin quality and actinic keratoses

Rejuvenat has its own DNA endonuclease repair enzymes built in, the same class of enzymes your cells use to detect and excise UV-damaged DNA. Combined with our proprietary GMA7 technology, targeted peptides for collagen and barrier resilience, and potent antioxidants to neutralize oxidative damage, this is what we consider the best DNA repair serum available. It sits within our broader custom compounded skincare program.

The translational data, presented at leading dermatology conferences under the title "Addressing the Field, Not Just the Lesion," showed that GMA7 reduced reactive oxygen species by 95.5% versus UV exposure, cut UV-induced inflammatory cytokines (IL-6) by 94%, and significantly upregulated VEGF for vascular repair. This is cellular-level defense, not just skincare.

Serum only, no laser: the measured results

Some of the most telling before-and-after results in our records are from Rejuvenat serum alone, with no laser involved, tracked over time with multi-spectral imaging: measured UV spots dropping from 4.10% to 1.31% in one case and from 4.11% to 1.84% in another, alongside objectively measured texture improvement and field clearance. Individual results vary, and these results reflect serum use without any laser treatment.

A personal story

I know what it feels like to hear "skin cancer." The cold shock. The way it rewires how you see your own skin. I have been that patient.

UV Spots analysis, serum only: 4.10% to 1.3% (female patient, left) and 4.11% to 1.84% (male patient, right)UV Spots analysis, serum only: 4.10% to 1.3% (female patient, left) and 4.11% to 1.84% (male patient, right)
UV Spots analysis, serum only: 4.10% to 1.3% (female patient, left) and 4.11% to 1.84% (male patient, right)

I looked for a system that combined prevention, treatment and accountability, not just lesion removal and a sunscreen pamphlet. The answer did not exist, so I built it. Every parameter, every protocol, every measurement carries the weight of knowing what it is like to be on the other side of that diagnosis. You can read more about my background here.

A new philosophy: stop hiding from the sun

Being outside is essential for internal longevity: vitamin D, circadian rhythm, mood, immunity. The sun is not the enemy. Unmanaged exposure is. Fear of the sun damages your hormones, mood and vitality; the goal is intelligent exposure. In practice that means traceability: we measure your UV burden, track your field, and adjust based on real data, so you can live in the sun without fear when the right parameters and DNA-repair support are in place.

Patient skin progression across three clinical timepoints
Patient skin progression across three clinical timepoints
This is not about hiding from the sun. It is about traceability, accountability, and allowing people to live their best life unapologetically.

Recognition

Los Angeles Magazine recognized Dr. Sajic with the 2025 Best of Beauty Pioneer Award, not for chasing trends, but for building a system that treats skin as a living organ deserving of real science, real measurement, and real accountability. The award specifically recognized Rejuvenat as "a breakthrough skincare product rooted in advanced dermatological science" and Dr. Sajic's signature 5 Dimension Skin Plan, which addresses aging from the inside out. It is the industry beginning to recognize that the future of beauty is longevity.

Los Angeles Magazine 2025 Best of Beauty Pioneer Award
Los Angeles Magazine 2025 Best of Beauty Pioneer Award

Frequently asked questions

What is Nordlys 1940nm and how is it different from CO2 laser?

Nordlys 1940nm is a non-ablative fractional laser that works at a wavelength targeting water in the skin. Unlike CO2, which ablates tissue and requires 2 to 3 weeks of downtime, 1940nm creates controlled microthermal zones without removing the surface. The 2026 Nature Scientific Reports study showed it reverses 83% of age-associated epigenetic changes, activating longevity markers similar to CO2 but with dramatically less recovery time.

Is Nordlys 1940nm proven to prevent skin cancer like Fraxel 1927?

Not yet specifically. Dr. Avram's data showed roughly a 50% skin cancer reduction with 1927nm NAFL over 6 years. The 1940nm wavelength activates different pathways, more longevity and youthful markers than cancer-specific ones. Given the adjacent mechanism, the direction is scientifically compelling, but we do not yet have long-term cancer-prevention data at 1940nm specifically. We are transparent about what the evidence shows and what remains to be proven.

Why do parameters and settings matter so much?

The same laser platform can produce dramatically different biological effects depending on energy density, pulse duration, coverage and depth. Settings optimized for a quick cosmetic glow may never reach the depth needed for epigenetic remodeling. We calibrate for skin vitality and longevity, not just appearance, and we measure whether the biology is actually changing.

What is GMA7 and how does Rejuvenat work with laser treatment?

GMA7 is our proprietary multi-active complex that engages core pathways in cutaneous aging: oxidative stress, inflammation (a 94% reduction in UV-induced IL-6 in translational testing), and senescence signaling. Rejuvenat delivers GMA7 plus beauty peptides daily, supporting the skin's DNA-repair machinery between laser sessions. The laser creates the reset; Rejuvenat maintains and extends it.

Can I still enjoy the sun with this approach?

Yes, that is the philosophy. We do not believe in hiding from the sun. Sun exposure is important for vitamin D, circadian rhythm, mood and overall longevity. Our approach is intelligent sun engagement: measure your UV damage burden, treat the field with appropriate laser parameters, support repair with DNA-repair skincare, and track your progress. Live unapologetically, with accountability.

How do I know if this is working for me specifically?

We measure before, during and after treatment using multi-spectral imaging (VISIA), Evolab Insight, and biological age tracking. Individual variation is real; some patients respond more strongly than others. If your response is suboptimal, we adjust parameters or add internal support. The plan is never one-size-fits-all, and we never hide behind assumptions.

Verifiable sources

The clinical claims in this article are drawn from the peer-reviewed literature and our own translational research below. The epigenetic data is from a first-in-human pilot study (n=22) and should be interpreted as promising early evidence.

Where this fits at Sajic Longevity. A clinical consult starts with measuring your skin's current biological state: UV damage burden, epigenetic age markers, and field quality. From there we build a protocol combining the right laser parameters with DNA-repair support. Book a consultation or call 1-888-430-4665.