A measured reset for the load of aging.
Clinical plasma exchange with 5% albumin replacement: a 90-minute session that clears accumulated molecular debris. Fifty years of clinical history, honest modern evidence, and outcomes we measure rather than promise.
Remove the old. Don't add the new.
Your plasma is separated from your blood cells, removed, and replaced with clean 5% albumin. Red cells, white cells and platelets are returned. The therapy has been used clinically since the 1960s and is first-line (ASFA Category I) for more than a dozen conditions.
For longevity, the logic follows the Conboy Lab's landmark finding: the benefit comes from diluting the old, inflammatory plasma environment, not from adding "young blood."
- Microplastics, found in 77% of human blood samples
- PFAS "forever chemicals" with half-lives of 3–8 years
- Inflammatory cytokines: IL-6, TNF-α, CRP
- Autoantibodies and immune complexes
- Senescent-cell signalling molecules
We publish the studies that didn't work, too.
What the trials show
Buck Institute / Circulate Health 2025 (Aging Cell): TPE with IVIG reduced biological age by 2.61 years in a placebo-controlled trial. Li et al. 2024 double-filtration data showed larger shifts. A JAMA Network Open 2022 RCT in 285 firefighters showed meaningful PFAS reduction. Conboy Lab 2020 established the dilution mechanism in mice.
What we tell you anyway
Borsky et al. 2025: plasmapheresis without albumin replacement showed no rejuvenation and accelerated aging clocks. Protocol details matter. A Long COVID RCT found no benefit, so we do not offer TPE for Long COVID.
What we measure per course: biological age (GrimAge, DunedinPACE), inflammatory load, autoantibody burden, toxin load, immune composition by flow cytometry, and cardiovascular risk markers (Lp(a), ApoB, oxidized LDL). Individual results vary.
Published pricing. Member advantage.
- Physician-guided protocol
- Pre- and post-session biomarker panels
- 5% albumin replacement
- Dedicated nurse, luxury treatment suite
- 4 sessions per year included in the Apex protocol
- Epigenetic clock tracking across the course
- Combined with your full longevity protocol
- Concierge coordination; discounted hotel stays can be arranged
Travel and accommodation are not included. Safety profile: transient citrate tingling, mild hypotension, rare albumin allergy; serious complications are rare (<1%) with experienced teams. Candidacy is determined at consultation.
Find out if TPE is right for you.
Candidacy is decided on your diagnostics, not your enthusiasm. Start with the numbers.
Apex Superhuman membership
Four TPE sessions a year included, at the $7,000 member rate thereafter.
Read more → BookBook a physician consultation
$499, applied to TruAge and bloodwork. Your pre-TPE baseline starts here.
Book now → DiagnosticsSee every diagnostic we run
150+ biomarkers, epigenetic age, multi-cancer screening and imaging.
See the panel →Not sure which is right for you? Call 1-888-430-4665 or email consult@sajicskin.com and our team will point you to the right starting point.