Treat the field,
not just the spot.
For every visible lesion, research suggests ten or more hidden, sub-clinical ones nearby. The field is the real treatment target, and field-directed care is prevention you can measure.
The lesion you can see is not the whole problem.
Spot treatment
Cryotherapy or curettage of individual lesions. Necessary at times, but incomplete: it ignores the damaged field around each spot.
Field treatment
5-FU, photodynamic therapy or laser resurfacing across the whole area. The modern standard.
High-density CO2
The most durable published option: lesion reduction of up to 90% sustained at 30 months in high-density protocols.
Durability is the honest metric.
At 30 months, the share of patients holding a 90%+ lesion reduction differs sharply by modality.
| Modality | Treats the field? | Durability at 30 months |
|---|---|---|
| 5-FU (topical chemotherapy) | Yes | ~4% hold the ≥90% threshold |
| Photodynamic therapy | Yes | ~9% hold the ≥90% threshold |
| Low-density CO2 | Yes | ~6% hold the ≥90% threshold |
| High-density CO2 | Yes | Best: up to 90% reduction sustained |
Figures reflect published clinical research; separate studies of non-ablative fractional lasers (1927nm) have shown roughly 50% reductions in new skin cancers over longer horizons. Each figure belongs to its own study and laser; individual results vary.
Internal support with real trial data.
Nicotinamide
In the ONTRAC phase-3 trial: roughly 23% fewer new non-melanoma skin cancers and 13–15% fewer actinic keratoses at 12 months.
Omega-3 fatty acids
Evidence for reduced UV-induced skin inflammation as part of the internal preparation layer.
DNA-repair & antioxidants
Rejuvenat's repair enzymes and antioxidant complex support the field between treatments, alongside daily mineral SPF.
Measured, as always: we baseline the field with VISIA and Evolab Insight imaging, treat it, and re-image, so prevention is a number you can watch, not a hope. Adjuncts are considered only after individual medical assessment. Read the science →
Treat the field, not just the spot.
Pre-cancerous damage is a field problem. Here is how to have it assessed and reset.
Skin cancer & aging: the same disease
The evidence that high-density CO2 clears actinic keratoses and resets the clock.
Read more → Book at the clinicRequest a clinic assessment
Mole mapping and field assessment at deRMA Skin Institute, Guelph.
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Sajic Skin Science DNA-repair and antioxidant protection, formulated by Dr. Sajic.
Shop now →Not sure which is right for you? Call 1-888-430-4665 or email consult@sajicskin.com and our team will point you to the right starting point.