A patient in their fifties sits down with me and lists everything they have heard about: CO2 laser, RF microneedling, Sculptra, peptides, hormones, biological age testing. Then they ask the question that actually matters. How often?

It deserves a straight answer, because cadence is where most plans fail. Too often, and you are managing inflammation you created. Not often enough, and you are maintaining nothing. And almost everyone is under-scheduling the one thing that tells them whether any of it is working.

1×full-face CO2 laser per year at most, and often once every 2 to 3 years
3–6months for biostimulator collagen to build after the appointment
3months between peptide and GLP-1 lab reviews
0protocols worth repeating that were never measured

The principle: depth and biology set the clock

Every treatment on this list works by triggering a biological response, usually a wound-healing and collagen-remodeling cascade. That response has its own timeline. New collagen is laid down and organized over months, not days. Booking the next session before the last one has finished working does not speed anything up. It just stacks inflammation on top of an unfinished repair.

So the interval is not a sales decision. It is set by how deep the treatment reaches, how long the tissue takes to respond, and what your measurements say.

Frequency isn't the plan. Frequency is what falls out of the plan once you've actually measured something.

The full cadence, category by category

These are typical intervals for an adult patient with healthy healing. They are starting points, not prescriptions. Skin type, history, medications and goals move all of them.

Resurfacing and laser

TreatmentTypical cadenceWhy
CO2 laser, full faceOnce a year at most. Often every 2 to 3 years.Depth does the work, not repetition. The remodeling runs for months after a single properly delivered session.
CO2 laser, targeted zone1 to 2 sessions, then reassess at 12 monthsSmaller areas can be staged, then measured before anything is repeated.
Red light2 to 4 times per week, ongoingSupportive, not a treatment on its own.

Collagen and structure

TreatmentTypical cadenceWhy
RF microneedlingA series of 3, spaced 4 to 6 weeks apart, then once a yearA series builds the result. Annual maintenance holds it.
UltherapyEvery 12 to 18 monthsLifting and tightening runs on a long clock.
Biostimulators (Sculptra, Radiesse)A vial series up front, then top up every 18 to 24 monthsThese build collagen, not volume. The effect keeps developing for 3 to 6 months after each session.
PRPA series of 3, then 1 to 2 times a yearYour own platelets. Series first, maintenance after.

Internal medicine

ProtocolTypical cadenceWhy
PeptidesReviewed every 3 monthsCycled, never continuous, and always checked against bloodwork.
GLP-1 (semaglutide, tirzepatide)Weekly dosing, labs every 3 monthsTracked against body composition, not just the scale, so muscle and facial volume are protected.
Hormone optimizationBloodwork every 3 to 6 monthsAdjusted continuously. Never set and forget.
IV nutrient therapyOnly when indicatedWhen a deficiency actually shows on a panel, not on a schedule.

Diagnostics: the part nobody schedules

MeasurementTypical cadenceWhy
Biological age (epigenetic testing)Every 6 to 12 monthsThe number that tells you whether any of this is working.
Skin analyticsEvery 3 to 6 monthsPhotodamage and skin health, measured under standardized imaging.
Full-body MRIAnnuallyRadiation free. We catch it first.
VO2 max & body compositionAnnuallyFitness and muscle mass age you faster than your face does.

The honest part. Most patients are getting more injectables and fewer measurements than they need. Repeating a treatment on schedule is easy. Proving it worked is the hard part, and it is the only part that compounds.

Book the physician consultation. $499 includes TruAge biological age testing. Your deposit is applied to further diagnostics. Book now →

A sample year, month by month

Here is what a real calendar can look like. This example is for a hypothetical 50-year-old with moderate sun damage, early laxity and a hormone protocol already in place, starting in October. It is an illustration of how the intervals fit together, not a plan for you. Yours is built after your baseline.

OctBaseline
  • Bloodwork & biological age
  • Skin analytics imaging
  • VO2 max & body composition
  • CO2 pre-care begins
NovLaser window
  • CO2 laser, full face (early Nov)
  • Recovery protocol
DecHeal
  • Healing check
  • Hormone bloodwork
  • Red light, 2 to 4x weekly
JanBuild
  • Biostimulator, session 1
  • Peptide review
  • Skin analytics re-image
FebBuild
  • Biostimulator, session 2
MarSeries
  • RF microneedling, 1 of 3
AprSeries
  • RF microneedling, 2 of 3
  • Peptide review
MaySeries
  • RF microneedling, 3 of 3
JunProtect
  • Hormone bloodwork
  • No resurfacing. SPF & repair skincare
JulCheck
  • Peptide review
  • Skin analytics re-image
AugScreen
  • Full-body MRI
SepRe-measure
  • Biological age re-test
  • VO2 max & body composition
  • Plan year two from the data

Not on this year's calendar: a second full-face CO2 laser (likely not needed for 2 to 3 years), a biostimulator top-up (18 to 24 months out), and annual RF microneedling maintenance (next spring). Count the in-clinic procedures: six. Count the measurements: more than that. That ratio is the point.

Why the dark months are resurfacing season

Notice the laser sits in November. That is deliberate. Healing skin is vulnerable to pigment change, and ultraviolet exposure is one of the biggest drivers of post-inflammatory hyperpigmentation after resurfacing. In Canada, UV levels drop sharply from October onward, so a CO2 laser in the fall is a different decision than the same laser in June. Downtime is also easier to take when you are indoors more and the social calendar has not yet peaked.

If you are planning for the season, these are the windows I would work back from:

  1. Biostimulators: book by October 1. Collagen takes 3 to 6 months to show. Start later and you are building it for spring.
  2. RF microneedling: start by October 1. A series of 3 takes about 12 weeks, and you want to finish two weeks clear of anything else.
  3. CO2 laser: aim for early November. UV drops, and so does pigment risk while skin heals. The fall is the window.
  4. Bloodwork and biological age: before December 31. A year-end baseline is what makes every number in January mean something.

If you miss those windows, that is fine. The sample year above starts collagen work in January for exactly that reason. The sequence matters more than the start date.

Sequencing: why the order matters as much as the interval

Stacking treatments too close together is one of the most common and most avoidable causes of complications. Each procedure creates a healing response, and two overlapping healing responses in the same tissue compete with each other. That is why, in the sample year, the CO2 laser heals fully before collagen stimulators begin, and the RF series runs on its own.

Internal readiness matters too. Elevated inflammation, low vitamin D, poor glucose control and hormonal deficiency all slow repair. That is why we run bloodwork before aggressive resurfacing, and sometimes delay the laser to fix the terrain first. I have written more about how combination protocols are sequenced and how to prepare for CO2 recovery.

What this means if you come to see me

  1. We start with measurement, not a treatment menu. Your baseline sets your calendar.
  2. Your intervals will be specific to you. Some patients need less than the ranges above, some need a different order entirely.
  3. Every repeat is earned. If the numbers are not moving, we change the protocol instead of repeating it.
  4. Measure, treat, measure again. That is the cadence underneath every other cadence.

Frequently asked questions

How often can you safely get a CO2 laser?

For a full-face treatment, once a year at most, and many patients only need one every 2 to 3 years. A properly delivered CO2 laser works through depth, and the collagen remodeling it triggers continues for months. Smaller targeted zones can sometimes be staged in 1 to 2 sessions and reassessed at 12 months. Your skin type, history and healing decide the final interval.

How often should I get Sculptra or Radiesse?

Biostimulators are usually given as a series up front, then topped up every 18 to 24 months. They build collagen gradually over 3 to 6 months after each session, so rebooking early does not accelerate the result.

How many RF microneedling sessions do I need?

A typical starting point is a series of 3, spaced 4 to 6 weeks apart, followed by one maintenance session a year. Some patients with more laxity or scarring need a different plan.

What is the best time of year for laser resurfacing?

In Canada, fall and early winter. Lower UV exposure reduces the risk of pigment change while skin heals, and downtime is easier to manage. Sun protection still matters year round.

How often should I test my biological age?

Every 6 to 12 months is a practical interval. Testing much more often rarely shows meaningful change, and testing less often makes it hard to tell which part of your protocol is doing the work.

Can I follow the sample calendar on my own?

No. It is an illustration of how intervals fit together for one hypothetical patient. Your plan should be built by a physician after a baseline assessment, because medications, skin type, medical history and goals change both the order and the spacing.